Science. 1991 Nov 29;254(5036):1385-7.

Regulation of a segmentation stripe by overlapping activators and repressors in the Drosophila embryo.

Source

Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027.

Abstract

Gene expression stripes in Drosophila melanogaster embryos provide a model for how eukaryotic promoters are turned on and off in response to combinations of transcriptional regulators. Genetic studies suggested that even-skipped (eve) stripe 2 is controlled by three gap genes, hunchback (hb), Kruppel (Kr), and giant (gt), and by the maternal morphogen bicoid (bcd). A direct link is established between binding sites for these regulatory proteins in the stripe 2 promoter element and the expression of the stripe during early embryogenesis. The bcd and hb protein binding sites mediate activation, whereas neighboring gt and Kr protein sites repress expression and establish the stripe borders. The stripe 2 element has the properties of a genetic on-off switch.

PMID:: 1683715; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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Oligodeoxyribonucleotides

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GM 34431/GM/NIGMS NIH HHS/United States

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Related citations in PubMed

Regulation of even-skipped stripe 2 in the Drosophila embryo. [EMBO J. 1992]
Regulation of even-skipped stripe 2 in the Drosophila embryo.
Small S, Blair A, Levine M. EMBO J. 1992 Nov; 11(11):4047-57.
Transcriptional regulation of a pair-rule stripe in Drosophila. [Genes Dev. 1991]
Transcriptional regulation of a pair-rule stripe in Drosophila.
Small S, Kraut R, Hoey T, Warrior R, Levine M. Genes Dev. 1991 May; 5(5):827-39.
The eve stripe 2 enhancer employs multiple modes of transcriptional synergy. [Development. 1996]
The eve stripe 2 enhancer employs multiple modes of transcriptional synergy.
Arnosti DN, Barolo S, Levine M, Small S. Development. 1996 Jan; 122(1):205-14.
Review The bicoid and dorsal morphogens use a similar strategy to make stripes in the Drosophila embryo. [J Cell Sci Suppl. 1992]
Review The bicoid and dorsal morphogens use a similar strategy to make stripes in the Drosophila embryo.
Ip YT, Levine M, Small SJ. J Cell Sci Suppl. 1992; 16:33-8.
Review Gap genes and gradients--the logic behind the gaps. [Bioessays. 1991]
Review Gap genes and gradients--the logic behind the gaps.
Hülskamp M, Tautz D. Bioessays. 1991 Jun; 13(6):261-8.

See reviews... See all...

Cited by 57 PubMed Central articles

Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness. [PLoS Genet. 2011]
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Temporal coordination of gene networks by Zelda in the early Drosophila embryo. [PLoS Genet. 2011]
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Nien CY, Liang HL, Butcher S, Sun Y, Fu S, Gocha T, Kirov N, Manak JR, Rushlow C. PLoS Genet. 2011 Oct; 7(10):e1002339. Epub 2011 Oct 20.
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