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1: J Negat Results Biomed. 2006 Jul 12;5:10.Click here to read Click here to read Links

Study of the impact of perilipin polymorphisms in a French population.

Meirhaeghe A, Thomas S, Ancot F, Cottel D, Arveiler D, Ferrières J, Amouyel P.

INSERM, U744, Lille, France. Aline.Meirhaeghe-Hurez@pasteur-lille.fr

BACKGROUND: Perilipins are proteins localized at the surface of the lipid droplet in adipocytes, steroid-producing cells and ruptured atherosclerotic plaques playing a role in the regulation of triglyceride deposition and mobilization. We investigated whether perilipin gene polymorphisms were associated with obesity, type 2 diabetes, and their related variables (anthropometric variables, plasma leptin, lipids, glucose and insulin concentrations) in a cross-sectional random sample of 1120 French men and women aged 35 to 65 years old, including 227 obese (BMI >or= 30 kg/m2) and 275 type 2 diabetes subjects. RESULTS: Among 7 perilipin polymorphisms tested, only 2 (rs4578621 and rs894160) of them were frequent enough to be fully investigated and we genotyped the sample using the PCR-RFLP method. No significant associations could be found between any of these polymorphisms and the studied phenotypes. CONCLUSION: The rs4578621 and rs894160 polymorphisms of the perilipin gene are not major genetic determinants of obesity and type 2 diabetes-related phenotypes in a random sample of French men and women.

PMID: 16836753 [PubMed - indexed for MEDLINE]

PMCID: PMC1538627