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Chemphyschem. 2006 Aug 11;7(8):1641-7.

DNA tile based self-assembly: building complex nanoarchitectures.

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  • 1Department of Chemistry and Biochemistry and The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.


DNA tile based self-assembly provides an attractive route to create nanoarchitectures of programmable patterns. It also offers excellent scaffolds for directed self-assembly of nanometer-scale materials, ranging from nanoparticles to proteins, with potential applications in constructing nanoelectronic/nanophotonic devices and protein/ligand nanoarrays. This Review first summarizes the currently available DNA tile toolboxes and further emphasizes recent developments toward self-assembling DNA nanostructures with increasing complexity. Exciting progress using DNA tiles for directed self-assembly of other nanometer scale components is also discussed.

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