Arch Pathol Lab Med. 2006 Jul;130(7):1075-6.

Epistaxis and severe weakness in a patient with multiple myeloma. Therapy-related acute myeloid leukemia, pure erythroid leukemia.

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Department of Pathology, New York University Medical Center, New York 10016, USA.

Abstract

Therapy-related acute myeloid leukemias arise as a result of cytotoxic chemotherapy and/or radiation therapy. The most common types of acute myeloid leukemia arising in this setting are acute myeloid leukemia with maturation, and lesser numbers of acute myelomonocytic leukemia, acute monocytic leukemia, acute erythroleukemia, or acute megakaryocytic leukemia. We present a patient with multiple myeloma who was treated with melphalan and 4 years later developed acute erythroid leukemia. The morphologic diagnosis of pure erythroid leukemia developing in the setting of multiple myeloma may be challenging.

PMID:: 16831041; [PubMed - indexed for MEDLINE]

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[Erythroleukemia in multiple myeloma. A case report]. [Schweiz Med Wochenschr. 1987]
[Erythroleukemia in multiple myeloma. A case report].
Streuli R, Voellmy W. Schweiz Med Wochenschr. 1987 Feb 21; 117(8):286-91.
Multiple myeloma and acute leukemia associated with alkylating agents. [Arch Intern Med. 1975]
Multiple myeloma and acute leukemia associated with alkylating agents.
Kyle RA, Pierre RV, Bayrd ED. Arch Intern Med. 1975 Jan; 135(1):185-92.
Review [Acute leukemia in multiple myeloma: case histories, a review of the literature and assessment of the incidence]. [Klin Wochenschr. 1979]
Review [Acute leukemia in multiple myeloma: case histories, a review of the literature and assessment of the incidence].
Bierbach H, Zeile G, Wellek S, Fischer J. Klin Wochenschr. 1979 Aug 1; 57(15):769-77.
Review Acute erythroid neoplastic proliferations. A biological study based on 62 patients. [Haematologica. 2002]
Review Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, et al. Haematologica. 2002 Feb; 87(2):148-53.
Erythroleukemia following melphalan therapy for multiple myeloma. [N Y State J Med. 1975]
Erythroleukemia following melphalan therapy for multiple myeloma.
Fishman SA, Ritz ND. N Y State J Med. 1975 Nov; 75(13):2402-4.

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Epistaxis and severe weakness in a patient with multiple myeloma. Therapy-relate...
Epistaxis and severe weakness in a patient with multiple myeloma. Therapy-related acute myeloid leukemia, pure erythroid leukemia.
Arch Pathol Lab Med. 2006 Jul ;130(7):1075-6.

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