Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trans R Soc Trop Med Hyg. 1991 May-Jun;85(3):349-55.

Modelling the development of resistance of Plasmodium falciparum to anti-malarial drugs.

Author information

  • 1Bristol Myers, Wallingford, Connecticut.

Abstract

A hybrid transmission/genetics model for the development of resistance by Plasmodium falciparum to anti-malarial drugs is set forth. Field data on pyrimethamine resistance are used to calibrate and test the model. Simulated consequences of different drug dosage and population coverage strategies are presented to illustrate an ethical dilemma. A strategy of maximally effective treatment for all infected individuals in the short term can be deleterious--in terms of rapid development of drug resistance--for a community in the longer term.

PMID:
1683034
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk