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Lancet. 1991 Nov 9;338(8776):1174-5.

Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine.

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  • 1Department of Neurology, University Hospital, Free University of Brussels, Belgium.


2 patients had neurological symptoms and signs, with evidence of central-nervous-system demyelination, 6 weeks after administration of recombinant hepatitis B vaccine. 1 had known multiple sclerosis but the other had no history of neurological disease; both had HLA haplotypes DR2 and B7, which are associated with multiple sclerosis. A causal link between vaccination and demyelination cannot be established from these 2 case-reports, but the time interval would fit a proposed immunological mechanism.

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