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Ugeskr Laeger. 2006 Jun 26;168(26-32):2568-70.

[Antenatal determination of fetal RhD-blood type based on fetal DNA in plasma from the RhD-negative mother--secondary publication].

[Article in Danish]

Author information

  • 1H:S Rigshospitalet, H:S Blodbank, KI 2034, DK-2100 København Ø. frederik.banch.clausen@rh.dk

Abstract

We present a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD-women. This test is needed for a future antenatal RH prophylaxis. A new real time PCR based assay targeting RHD exon 7 and a published assay for RHD exon 10 were used to determine the fetal RHD status in DNA extracted from plasma from 56 pregnant women in 15th-36th week of gestation. Prediction of fetal RhD type was compared with the phenotype determined after birth, and showed 100% concordance. This setup will be of value in antenatal RH prophylaxis and in the management of immunised women.

PMID:
16824414
[PubMed - indexed for MEDLINE]
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