J Am Anim Hosp Assoc. 2006 Jul-Aug;42(4):302-7.

Use of posaconazole in the management of invasive orbital aspergillosis in a cat.

McLellan GJ, Aquino SM, Mason DR, Kinyon JM, Myers RK.

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Departments of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250, USA.

Abstract

Orbital infection with Aspergillus fumigatus was diagnosed in a Persian cat that was presented with chronic third eyelid protrusion and exophthalmos. Evidence of nasal, sinus, or disseminated aspergillosis was not detected in this cat. Complete surgical excision of diseased tissues was not possible during orbital exenteration, and infection subsequently extended into the tissues of the oral cavity. Oral therapy with itraconazole and parenteral therapy with amphotericin B were ineffective in resolving the infection. Oral therapy with a novel triazole, posaconazole, was curative.

PMID:: 16822770; [PubMed - indexed for MEDLINE]

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