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Ann Hepatol. 2006 Apr-Jun;5(2):92-6.

Clinical and virological features of acute HBV-related hepatitis in southern Vietnam.

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  • 1Hospital for Tropical Disease, Ho Chi Minh city, Vietnam.

Abstract

BACKGROUND:

Despite the availability of effective vaccines, hepatitis B virus (HBV) infection is still frequent worldwide, and accounts for significant morbidity and mortality. However, data of acute HBeAg negative hepatitis still remain limited.

AIMS AND METHODS:

To understand clinical pictures of acute HBV hepatitis and its natural evolution, a prospective study was conducted in adult patients.

RESULTS:

Ninety patients were enrolled between March 2004 and April 2005 at Hospital for Tropical Diseases in Ho Chi Minh city. The prevalence of HBeAg negative was 53%. No significant difference was found in clinical characteristics and laboratory findings between HBeAg positive and negative patients. HBV-DNA was detected in 75% and 88% HBe negative and positive patients, respectively, where the frequency of ALT below 400 U/L was significantly higher in HBeAg negative cases (p= 0.01). Six month follow-up was available in 47 patients. HBsAg positivity was found in 16% of HBeAg negative subjects but only in 4.5% of HBeAg positive cases. Thirty two patients had neither HBsAg nor anti-HBs.

CONCLUSIONS:

The clinical laboratory feature and the outcome at 6 months of HBV acute hepatitis in Vietnam is similar in HBeAg positive and negative patients.

PMID:
16821281
[PubMed - indexed for MEDLINE]
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