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Semin Pediatr Neurol. 2006 Mar;13(1):8-20.

Cognitive profile of neurofibromatosis type 1.

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  • 1Kennedy Krieger Institute, Department of Developmental Cognitive Neurology, Baltimore, MD 21205, USA.


General consensus has yet to be reached with regard to the exact cognitive profile of children with neurofibromatosis type 1 (NF1). The current overview seeks to provide a more comprehensive review of the literature by examining studies that have specifically compared individuals with NF1 to siblings, controls, and/or norms. We also examined results of studies that compared individuals with NF1 with various manifestations to each other. Consistent with previous reviews, no clear cognitive profile emerged; however, greater insight into patterns was obtained. Additionally, future directions for research on NF1 were suggested.

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