Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br J Psychiatry. 2006 Jul;189:20-5.

Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders.

Author information

  • 1Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. mwotto@bu.edu

Abstract

BACKGROUND:

The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder.

AIMS:

To examine the association between anxiety and course of bipolar disorder, as defined by mood episodes, quality of life and role functioning.

METHOD:

A thousand thousand out-patients with bipolar disorder were followed prospectively for 1 year.

RESULTS:

A current comorbid anxiety disorder (present in 31.9% of participants) was associated with fewer days well, a lower likelihood of timely recovery from depression, risk of earlier relapse, lower quality of life and diminished role function over I year of prospective study. The negative impact was greater with multiple anxiety disorders.

CONCLUSIONS:

Anxiety disorders, including those present during relative euthymia, predicted a poorer bipolar course. The detrimental effects of anxiety were not simply a feature of mood state. Treatment studies targeting anxiety disorders will help to clarify the nature of the impact of anxiety on bipolar course.

PMID:
16816301
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk