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Trends Endocrinol Metab. 2006 Aug;17(6):251-8. Epub 2006 Jun 30.

Membrane guanylyl cyclase receptors: an update.

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  • 1Cecil H. & Ida Green Center for Reproductive Biology Sciences, and Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9051, USA. david.garbers@utsouthwestern.edu


Recent studies have demonstrated key roles for several membrane guanylyl cyclase receptors in the regulation of cell hyperplasia, hypertrophy, migration and extracellular matrix production, all of which having an impact on clinically relevant diseases, including tissue remodeling after injury. Additionally, cell differentiation, and even tumor progression, can be profoundly influenced by one or more of these receptors. Some of these receptors also mediate important communication between the heart and intestine, and the kidney to regulate blood volume and Na+ balance.

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