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J Affect Disord. 2006 Nov;96(1-2):127-31. Epub 2006 Jun 30.

Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness.

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  • 1Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA. Richard_Rende@Brown.edu

Abstract

BACKGROUND:

Few studies have examined the specificity and non-specificity in patterns of familial loading for presentation of psychotic symptoms in pediatric bipolar disorder (BP).

METHODS:

Diagnostic assessment of 263 pediatric BP probands included lifetime history of psychotic symptoms as well as longitudinal follow-up; family history of psychiatric illness was determined for 1st degree relatives.

RESULTS:

Pediatric BP probands with lifetime history of psychosis had a higher percentage of positive family history of anxiety disorders and suicide attempts as compared to probands with no history of psychosis.

DISCUSSION:

Familial loading for a spectrum of internalizing disorders is associated with presentation of psychotic symptoms in pediatric BP.

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