Lancet. 1991 Oct 5;338(8771):851-2.

Is postoperative delirium related to reduced plasma tryptophan?

van der Mast RC, Fekkes D, Moleman P, Pepplinkhuizen L.

Source

Department of Psychiatry, Dijkzigt Hospital, Rotterdam, Netherlands.

Abstract

The cause of postoperative delirium is unknown. In 7 patients with postcardiotomy delirium (6 men, 1 woman; mean age 67 years), we observed a plasma concentration of tryptophan and a plasma tryptophan ratio significantly lower than in 8 non-delirious postoperative control patients. We suggest that the mental symptoms of postcardiotomy delirium are the consequence of a reduced cerebral tryptophan availability due to a catabolic state.

Comment in

PMID:: 1681217; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Tryptophan

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

(L)-TRYPTOPHAN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Is delirium after cardiac surgery related to plasma amino acids and physical condition? [J Neuropsychiatry Clin Neurosc...]
Is delirium after cardiac surgery related to plasma amino acids and physical condition?
van der Mast RC, van den Broek WW, Fekkes D, Pepplinkhuizen L, Habbema JD. J Neuropsychiatry Clin Neurosci. 2000 Winter; 12(1):57-63.
Incidence of and preoperative predictors for delirium after cardiac surgery. [J Psychosom Res. 1999]
Incidence of and preoperative predictors for delirium after cardiac surgery.
van der Mast RC, van den Broek WW, Fekkes D, Pepplinkhuizen L, Habbema JD. J Psychosom Res. 1999 May; 46(5):479-83.
Delirium after cardiac surgery. The possible role of tryptophan in relation to the other neutral aminoacids. [Adv Exp Med Biol. 1996]
Delirium after cardiac surgery. The possible role of tryptophan in relation to the other neutral aminoacids.
van der Mast RC, van den Broek WW, Fekkes D, Pepplinkhuizen L, Roest FH. Adv Exp Med Biol. 1996; 398:93-6.
Review Postcardiotomy delirium: a critical review. [J Thorac Cardiovasc Surg. 1979]
Review Postcardiotomy delirium: a critical review.
Dubin WR, Field HL, Gastfriend DR. J Thorac Cardiovasc Surg. 1979 Apr; 77(4):586-94.
Review Postoperative delirium and plasma melatonin. [Med Hypotheses. 1999]
Review Postoperative delirium and plasma melatonin.
Uchida K, Aoki T, Ishizuka B. Med Hypotheses. 1999 Aug; 53(2):103-6.

See reviews... See all...

Cited by 4 PubMed Central articles

Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients. [Crit Care. 2011]
Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients.
McGrane S, Girard TD, Thompson JL, Shintani AK, Woodworth A, Ely EW, Pandharipande PP. Crit Care. 2011; 15(2):R78. Epub 2011 Mar 2.
Low tryptophan levels are associated with postoperative delirium in the elderly. [Am J Surg. 2008]
Low tryptophan levels are associated with postoperative delirium in the elderly.
Robinson TN, Raeburn CD, Angles EM, Moss M. Am J Surg. 2008 Nov; 196(5):670-4. Epub 2008 Sep 11.
Risk factors for delirium in acutely admitted elderly patients: a prospective cohort study. [BMC Geriatr. 2005]
Risk factors for delirium in acutely admitted elderly patients: a prospective cohort study.
Korevaar JC, van Munster BC, de Rooij SE. BMC Geriatr. 2005 Apr 13; 5:6. Epub 2005 Apr 13.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Is postoperative delirium related to reduced plasma tryptophan?
Is postoperative delirium related to reduced plasma tryptophan?
Lancet. 1991 Oct 5 ;338(8771):851-2.

PubMed
Concurrent schedule assessment of food preference in cows.
Concurrent schedule assessment of food preference in cows.
J Exp Anal Behav. 1979 Sep ;32(2):245-54.

PubMed
Pulsatility index in internal carotid artery in relation to transdermal oestradi...
Pulsatility index in internal carotid artery in relation to transdermal oestradiol and time since menopause.
Lancet. 1991 Oct 5 ;338(8771):839-42.

PubMed
The effect of punishment on free-operant choice behavior in humans.
The effect of punishment on free-operant choice behavior in humans.
J Exp Anal Behav. 1979 Jan ;31(1):71-81.

PubMed
Iron in neuroleptic malignant syndrome.
Iron in neuroleptic malignant syndrome.
Lancet. 1991 Sep 28 ;338(8770):820-1.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: