Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2006 Aug;22(8):412-6. Epub 2006 Jun 30.

The quest for the universals of protein evolution.

Author information

  • Unité Génomique des Génomes Bactériens, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France. erocha@abi.snv.jussieu.fr

Abstract

The sequences of proteins change at dramatically different rates. Unraveling the association between this variability and cellular and ecological processes will enable a better understanding of protein function and evolution. Although weak associations of protein evolutionary rates with a plethora of variables have been reported, none withstands comparison with the effect of expression levels. A recent report by Drummond et al. suggests that the dominant role of expression levels in slowing the rate of protein evolution stems from selection for translation robustness.

PMID:
16808987
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk