FEBS Lett. 1991 Sep 23;290(1-2):157-8.

Heterogeneity in human soluble guanylate cyclase due to alternative splicing.

Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE.

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Department of Pharmacology, Umeå University, Sweden.

Abstract

Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.

PMID:: 1680753; [PubMed - indexed for MEDLINE]

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Cited by 4 PubMed Central articles

Alpha1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity. [J Biol Chem. 2008]
Alpha1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity.
Sharina IG, Jelen F, Bogatenkova EP, Thomas A, Martin E, Murad F. J Biol Chem. 2008 May 30; 283(22):15104-13. Epub 2008 Apr 1.
Genomic organization of alpha1 and beta1 subunits of the mammalian soluble guanylyl cyclase genes. [Proc Natl Acad Sci U S A. 2000]
Genomic organization of alpha1 and beta1 subunits of the mammalian soluble guanylyl cyclase genes.
Sharina IG, Krumenacker JS, Martin E, Murad F. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10878-83.
Alternative splicing for the alpha1 subunit of soluble guanylate cyclase. [Biochem J. 2000]
Alternative splicing for the alpha1 subunit of soluble guanylate cyclase.
Ritter D, Taylor JF, Hoffmann JW, Carnaghi L, Giddings SJ, Zakeri H, Kwok PY. Biochem J. 2000 Mar 15; 346 Pt 3:811-6.

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