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    Trends Cell Biol. 2006 Aug;16(8):421-6. Epub 2006 Jun 27.

    Coronins: the return of the crown.

    Uetrecht AC, Bear JE.

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    Lineberger Comprehensive Cancer Center and Department of Cell & Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

    Abstract

    Coronins are highly conserved regulators of the actin cytoskeleton whose structure and biological function have remained mysterious until recently. They were originally identified in Dictyostelium, where they localize to actin-rich crown-like structures on the dorsal surface of cells. Coronins bind filamentous actin and the Arp2/3 complex and are involved in modulating actin dynamics. Unlike other known Arp2/3-binding proteins, coronins inhibit Arp2/3 nucleating activity. Genetic data from Dictyostelium, yeast and Drosophila indicate that coronins are important regulators of several actin-dependent physiological processes. Here, we review recent insights into mammalian coronin structure, function and regulation and identify key questions that remain unanswered in this field.

    PMID:
    16806932
    [PubMed - indexed for MEDLINE]

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