Am J Respir Cell Mol Biol. 1991 Sep;5(3):206-10.

Properties and function of lysyl oxidase.

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Department of Biochemistry, Boston University School of Medicine, Massachusetts.

Abstract

Lysyl oxidase catalyzes the oxidation of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone. The proposed mechanism of action is derived from available kinetic and chemical data and also can account for mechanism-based inhibition of the enzyme by specific monoamines and diamines. Recent evidence for biosynthetic precursors and for the regulation of lysyl oxidase in fibrotic and malignant diseases is discussed.

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Am J Respir Cell Mol Biol. 1991 Sep;5(3):205.

PMID:: 1680355; [PubMed - indexed for MEDLINE]

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Protein-Lysine 6-Oxidase

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Cited by 17 PubMed Central articles

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