Predictors of outcome after temporal lobectomy for the treatment of intractable epilepsy.
Jeha LE,
Najm IM,
Bingaman WE,
Khandwala F,
Widdess-Walsh P,
Morris HH,
Dinner DS,
Nair D,
Foldvary-Schaeffer N,
Prayson RA,
Comair Y,
O'Brien R,
Bulacio J,
Gupta A,
Lüders HO.
Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. jehil@ccf.org
To assess short- and long-term seizure freedom, the authors reviewed 371 patients who underwent anterior temporal lobectomy to treat pharmacoresistant epilepsy. The mean follow-up duration was 5.5 years (range 1 to 14.1 years). Fifty-three percent of patients were seizure free at 10 years. The authors identified multiple predictors of recurrence. Results of EEG performed 6 months postoperatively correlated with occurrence and severity of seizure recurrence, in addition to breakthrough seizures with discontinuation of antiepileptic drugs.
PMID: 16801667 [PubMed - indexed for MEDLINE]