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J Cell Biol. 2006 Jul 3;174(1):11-7. Epub 2006 Jun 26.

Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER.

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  • 1Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.

Abstract

Peroxisomes have long been viewed as semiautonomous, static, and homogenous organelles that exist outside the secretory and endocytic pathways of vesicular flow. However, growing evidence supports the view that peroxisomes actually constitute a dynamic endomembrane system that originates from the endoplasmic reticulum. This review highlights the various strategies used by evolutionarily diverse organisms for coordinating the flow of membrane-enclosed carriers through the peroxisomal endomembrane system and critically evaluates the dynamics and molecular mechanisms of this multistep process.

PMID:
16801391
[PubMed - indexed for MEDLINE]
PMCID:
PMC2064154
Free PMC Article

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