Protein Pept Lett. 2006;13(5):467-9.

Deciphering signaling control by phosphoproteome using mass spectrometry.

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Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. leungyk@ucmail.uc.edu

Abstract

Analysis of changes in genes and protein profiles provides invaluable information to understand the activities and functions of proteins. However, their activities are further regulated by post-translational modifications, such as glycosylation and phosphorylation. Cell growth and apoptotic pathways are good examples of demonstrating the roles of phosphorylation in activation of protein cascades upon stimulation.

PMID:: 16800799; [PubMed - indexed for MEDLINE]

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