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J Assoc Physicians India. 2006 Mar;54:238-40.

Macrophage activation syndrome.

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  • 1Department of Internal Medicine, Medical College Hospital, Trivandrum.


Macrophage Activation Syndrome is a rare and potentially fatal disease, to be considered in patients with a SIRS like clinical presentation. Falling ESR and hyperferritinemia in the appropriate clinical setting can be the greatest clues. We report a case in which a female admitted with fever and rash, initially had systemic inflammatory response syndrome (SIRS) like clinical presentation, but eventually proved to be a rare case of fatal Macrophage Activation Syndrome.

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