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Transplant Proc. 2006 Jun;38(5):1274-9.

Clinical trial of Tripterygium Wilfordii Hook F. in human kidney transplantation in China.

Author information

  • 1Research Institute of Nephrology, Jinling Hospital, and Nanjing University School of Medicine, People's Republic of China. jishuming@vip.163.com

Abstract

OBJECTIVE:

In this study, the effects of Triptergium Wilfordii Hook F.(T II) were assessed on human kidney allograft rejection and long-term survival.

METHODS:

This study compared treatment with T II(T II group, n=121) to that without T II(control group, n=102) among adult first cadaveric renal transplant recipients. The T II cohort of 121 recipients were divided into a regular dosage group (n=82) and a double dosage group (n=39). No antibody induction was administered to any patient.

RESULTS:

Biopsy-proven early acute allograft rejection occurred in 4.1% of patients in the T II group versus 24.5% of patients in the control group. No rejection or repeated rejections occurred in the double dosage group at 3 months after transplantation. Acute rejection episodes were milder in the T II than the control group. The incidence of CD25+ cells>10/ mm3 in the allografts at 3 months after transplantation was lower in the T II group than the control group, 15% and 50%, respectively. All patients tolerated T II well over the 5 years of this study. The 5-year graft survival censored for death with function was 96.7% in the T II group and 80.4% in the control group.

CONCLUSION:

T II was effective to prevent renal allograft rejection and increase long-term renal allograft survival among adult cadaveric renal transplant recipients.

PMID:
16797280
[PubMed - indexed for MEDLINE]
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