Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Cancer. 2006 Jul;6(7):535-45.

Photodynamic therapy and anti-tumour immunity.

Author information

  • 1Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Abstract

Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.

PMID:
16794636
[PubMed - indexed for MEDLINE]
PMCID:
PMC2933780
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk