Angiogenesis in atherogenesis

Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):1948-57. doi: 10.1161/01.ATV.0000233387.90257.9b. Epub 2006 Jun 22.

Abstract

Atherogenesis is the pathobiological process, which underlies atherosclerotic cardiovascular disease and evolves in the 3 stages of initiation, progression, and complication to clinical significance. Of note, this process is associated with neovascularization, and it was not until recently that the implications of angiogenesis in atherogenesis were delineated. This article gives an updated overview on this topic and briefly reflects on the similarities with neovessel formation in carcinogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inducing Agents / metabolism
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Atherosclerosis / complications*
  • Atherosclerosis / drug therapy
  • Atherosclerosis / metabolism
  • Humans
  • Neovascularization, Pathologic / etiology*

Substances

  • Angiogenesis Inducing Agents
  • Angiogenesis Inhibitors