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Schizophr Res. 2006 Oct;87(1-3):223-7. Epub 2006 Jun 21.

Visuospatial working memory deficits in adolescent onset schizophrenia.

Author information

  • 1Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne and Royal Children's Hospital and Murdoch Childrens Research Institute, Parkville, 3052, Victoria, Australia. avance@unimelb.edu.au

Abstract

This study determines that visuospatial working memory (VSWM) deficits are evident in adolescent-onset schizophrenia, while the spatial strategy and spatial span components of VSWM are spared. These findings imply that frontal-striatal-parietal neural networks are dysfunctional in adolescent-onset schizophrenia, while mid-dorsolateral and ventrolateral PFC functions remain intact: the current conceptualisation of schizophrenia as a progressive neurodevelopmental disorder is consistent with these results.

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