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Nature. 2006 Jun 22;441(7096):947-52.

Genetic mechanisms and evolutionary significance of natural variation in Arabidopsis.

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  • 1Department of Biology, PO Box 91000, Duke University, Durham, North Carolina 27708, USA. tmo1@duke.edu


Genomic studies of natural variation in model organisms provide a bridge between molecular analyses of gene function and evolutionary investigations of adaptation and natural selection. In the model plant species Arabidopsis thaliana, recent studies of natural variation have led to the identification of genes underlying ecologically important complex traits, and provided new insights about the processes of genome evolution, geographic population structure, and the selective mechanisms shaping complex trait variation in natural populations. These advances illustrate the potential for a new synthesis to elucidate mechanisms for the adaptive evolution of complex traits from nucleotide sequences to real-world environments.

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