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1: Infect Immun. 2006 Jul;74(7):4366-9.Click here to read Click here to read Links

Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain.

Bader T, Schröppel K, Bentink S, Agabian N, Köhler G, Morschhäuser J.

Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany.

By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMP1 did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche.

PMID: 16790813 [PubMed - indexed for MEDLINE]

PMCID: PMC1489686