Hum Genet. 1991 Aug;87(4):506-8.

Exclusion of linkage between familial Mediterranean fever and the human serum amyloid A (SAA) gene cluster.

Sack GH Jr, Talbot CC Jr, McCarthy BG, Harris EL, Kastner D, Gruberg L, Pras M.

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Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Abstract

We studied the relationship between the autosomal recessive trait familial Mediterranean fever (FMF) and the serum amyloid A (SAA) genes by comparing alleles of a highly polymorphic dinucleotide repeat and a conventional restriction fragment length polymorphism (RFLP) in the SAA gene cluster in Israeli FMF kindreds. By haplotype analysis, our data indicate a minimum crossover frequency of 22% between the SAA gene marker and FMF. By conventional linkage analysis this eliminates a minimum of 10.4 cM including and surrounding the SAA gene cluster as the site of the FMF mutation although SAA proteins are prominent physiologic markers of the acute attacks.

PMID:: 1679035; [PubMed - indexed for MEDLINE]

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Serum Amyloid A Protein

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