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Lasers Surg Med. 2006 Jun;38(5):494-9.

Local physiological changes during photodynamic therapy.

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  • 1Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6072, USA. buschtm@mail.med.upenn.edu

Abstract

BACKGROUND AND OBJECTIVE:

Herein an overview is provided of the causes, consequences, and significance of photodynamic therapy (PDT)-mediated effects on tumor oxygenation and blood flow during illumination.

STUDY DESIGN/MATERIALS AND METHODS:

Techniques particularly valuable to this research have included tissue oxygen tension measurement by the Eppendorf pO2 Histograph; spatial quantification of hypoxia by EF3 and EF5; and tissue oxygenation/blood flow monitoring by diffuse reflectance/correlation spectroscopy.

RESULTS:

Severe hypoxia was measured in vivo during PDT and is shown to be a consequence of photochemical oxygen consumption and/or compromised vascular perfusion. Oxygen depletion can be controlled by treatment regimen, occurs in a spatially-definable pattern, and is therapy-limiting. PDT-induced changes in tumor oxygenation during illumination are correlated with outcome. In PDT-treated tissues, blood flow also is determined by treatment regimen and correlates with treatment response.

CONCLUSIONS:

Photodynamic therapy creates distinct, measurable changes in tumor oxygen and blood flow during illumination. These physiological changes may ultimately affect treatment efficacy.

Copyright 2006 Wiley-Liss, Inc.

[PubMed - indexed for MEDLINE]
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