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Nat Immunol. 2006 Jul;7(7):709-14.

Thymic stromal lymphopoietin in normal and pathogenic T cell development and function.

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  • 1Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA.


Thymic stromal lymphopoietin, a four helix-bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells. TSLP influences the outcome of interactions between dendritic cells and CD4+ thymocytes and T cells in many situations, such as the regulation of the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of CD4+ T cell-mediated allergic inflammation.

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