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Biol Psychiatry. 2006 Oct 15;60(8):837-42. Epub 2006 Jun 14.

Acute depressed mood as a trigger of acute coronary syndromes.

Author information

  • 1Department of Epidemiology and Public Health, University College London, London, UK. a.steptoe@ucl.ac.uk

Abstract

BACKGROUND:

Some cases of acute coronary syndrome (ACS) may be triggered by emotional states such as anger, but it is not known if acute depressed mood can act as a trigger.

METHODS:

295 men and women with a verified ACS were studied. Depressed mood in the two hours before ACS symptom onset was compared with the same period 24 hours earlier (pair-matched analysis), and with usual levels of depressed mood, using case-crossover methods.

RESULTS:

46 (18.2%) patients experienced depressed mood in the two hours before ACS onset. The odds of ACS following depressed mood were 2.50 (95% confidence intervals 1.05 to 6.56) in the pair-matched analysis, while the relative risk of ACS onset following depressed mood was 4.33 (95% confidence intervals 3.39 to 6.11) compared with usual levels of depressed mood. Depressed mood preceding ACS onset was more common in lower income patients (p = .032), and was associated with recent life stress, but was not related to psychiatric status.

CONCLUSIONS:

Acute depressed mood may elicit biological responses that contribute to ACS, including vascular endothelial dysfunction, inflammatory cytokine release and platelet activation. Acute depressed mood may trigger potentially life-threatening cardiac events.

PMID:
16780810
[PubMed - indexed for MEDLINE]
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