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Cell. 2006 Jun 16;125(6):1193-205.
Exploring transcriptional regulatory networks in the worm.
Department of Biological Physics and HAS Group, Eötvös University, Budapest 1117, Hungary.
Using a yeast one-hybrid assay, Deplancke et al. (2006) report in this issue a protein-DNA interaction network for 72 gene promoters and 117 regulatory proteins expressed in cells of the nematode digestive tract. This study is a first step toward mapping transcriptional regulatory networks in distinct metazoan cell lineages and organs using a "gene-centered" approach.
PMID: 16777593 [PubMed - indexed for MEDLINE]
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