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    Phytochemistry. 2006 Jun;67(12):1243-8. Epub 2006 Jun 14.

    Cytotoxic clerodane diterpenoids from the leaves of Premna tomentosa.

    Chin YW, Jones WP, Mi Q, Rachman I, Riswan S, Kardono LB, Chai HB, Farnsworth NR, Cordell GA, Swanson SM, Cassady JM, Kinghorn AD.

    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

    Three clerodane diterpenoids, premnones A-C (1-3), were isolated from a chloroform-soluble fraction of Premna tomentosa along with four known flavonoids and three known triterpenoids. Among these isolates, premnones A-C exhibited cytotoxic activity when evaluated against a small panel of tumor cell lines. However, premnone A was found to be inactive when evaluated in a follow-up in vivo hollow fiber assay at the highest dose tested (50mg/kg), using LNCaP, Lu1, and MCF-7 cells.

    PMID: 16777158 [PubMed - indexed for MEDLINE]

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