Cell Cycle. 2006 Jun;5(12):1313-9. Epub 2006 Jun 15.

The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability.

Source

Division of Cell & Molecular Biology, Faculty of Natural Sciences, Imperial College London, South Kensington, London, UK. emma.child@imperial.ac.uk

Abstract

p21 was originally described as functioning as a cell cycle regulator via inhibition of both cyclin-dependent kinases and processive DNA replication. Nowadays it is recognized to play other fundamental roles including transcriptional regulation and the modulation of apoptosis. Each of these functions of p21 is achieved through direct p21/protein interactions and the subcellular localization of p21 plays an important part in dictating the binding partners to which p21 is exposed. Over recent years, a number of phosphorylation sites in p21 have been identified, these being targeted by several important intracellular signalling protein kinases. Here we review the state of our knowledge of p21 phosphorylation with respect to the kinases involved and the molecular biological effects of each phosphorylation event.

PMID:: 16775416; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Landes Bioscience

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

The diverging roles of calmodulin and PKC in the regulation of p21 intracellular localization. [Cell Cycle. 2006]
The diverging roles of calmodulin and PKC in the regulation of p21 intracellular localization.
Agell N, Jaumot M, Rodríguez-Vilarrupla A, Brun S, Abella N, Canela N, Estanyol JM, Bachs O. Cell Cycle. 2006 Jan; 5(1):3-6. Epub 2006 Jan 26.
Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo. [Mol Cell Biol. 2007]
Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo.
Zhan J, Easton JB, Huang S, Mishra A, Xiao L, Lacy ER, Kriwacki RW, Houghton PJ. Mol Cell Biol. 2007 May; 27(9):3530-41. Epub 2007 Feb 26.
On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells. [Pancreas. 2006]
On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells.
Salabat MR, Ding XZ, Flesche JB, Ujiki MB, Robin TP, Talamonti MS, Bell RH Jr, Adrian TE. Pancreas. 2006 Aug; 33(2):148-55.
Review PhosphoSerine/threonine binding domains: you can't pSERious? [Structure. 2001]
Review PhosphoSerine/threonine binding domains: you can't pSERious?
Yaffe MB, Smerdon SJ. Structure. 2001 Mar 7; 9(3):R33-8.
Review The regulation of protein phosphorylation. [Biochem Soc Trans. 2009]
Review The regulation of protein phosphorylation.
Johnson LN. Biochem Soc Trans. 2009 Aug; 37(Pt 4):627-41.

See reviews... See all...

Cited by 27 PubMed Central articles

Activation of p21-Dependent G1/G2 Arrest in the Absence of DNA Damage as an Antiapoptotic Response to Metabolic Stress. [Genes Cancer. 2011]
Activation of p21-Dependent G1/G2 Arrest in the Absence of DNA Damage as an Antiapoptotic Response to Metabolic Stress.
Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA. Genes Cancer. 2011 Sep; 2(9):889-99.
Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibition. [PLoS One. 2011]
Serum-nutrient starvation induces cell death mediated by Bax and Puma that is counteracted by p21 and unmasked by Bcl-x(L) inhibition.
Braun F, Bertin-Ciftci J, Gallouet AS, Millour J, Juin P. PLoS One. 2011; 6(8):e23577. Epub 2011 Aug 24.
Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation. [PLoS One. 2011]
Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation.
Dudley KJ, Sloboda DM, Connor KL, Beltrand J, Vickers MH. PLoS One. 2011; 6(7):e21662. Epub 2011 Jul 11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The intricacies of p21 phosphorylation: protein/protein interactions, subcellula...
The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability.
Cell Cycle. 2006 Jun ;5(12):1313-9. Epub 2006 Jun 15 .

PubMed
Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the ...
Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain.
Neuromolecular Med. 2006 ;8(3):337-52.

PubMed
Residual human immunodeficiency virus type 1 viremia in some patients on antiret...
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells.
J Virol. 2006 Jul ;80(13):6441-57.

PubMed
Visualization of intracellular transport of vesicular stomatitis virus nucleocap...
Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells.
J Virol. 2006 Jul ;80(13):6368-77.

PubMed
Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus...
Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 gag cause a late budding defect.
J Virol. 2006 Jul ;80(13):6267-75.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: