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Neurology. 2006 Aug 8;67(3):497-9. Epub 2006 Jun 14.

Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen.

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  • 1Department of Neurology, University of M√ľnster, Germany. everss@uni-muenster.de


The authors conducted a double-blind, placebo-controlled, crossover study to investigate the efficacy of oral zolmitriptan in the treatment of migraine in children and adolescents. Patients (n = 32) received placebo, zolmitriptan 2.5 mg, and ibuprofen 200 to 400 mg to treat three consecutive migraine attacks. Pain relief rates after 2 hours were 28% for placebo, 62% for zolmitriptan, and 69% for ibuprofen (p < 0.05). Both drugs are well tolerated with only mild side effects.

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