Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Drug Discov. 2006 Jul;5(7):549-63. Epub 2006 Jun 9.

Targeting signal transduction as a strategy to treat inflammatory diseases.

Author information

  • 1School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland. laoneill@tcd.ie

Abstract

Inflammatory diseases are a major burden on humanity, despite recent successes with biopharmaceuticals. Lack of responsiveness and resistance to these drugs, delivery problems and cost of manufacture of biopharmaceuticals mean that the search for new anti-inflammatory agents continues. Progress in our understanding of inflammatory signalling pathways has identified new targets, notably in pathways involving NF-kappaB, p38 MAP kinase, T lymphocyte activation and JAK/STAT. Other targets such as transcription factor complexes and components of pathways activated by TNF, Toll-like receptors and Nod-like receptors also present possibilities, and might show efficacy without being limited by effects on host defence. The challenge is to place a value on one target relative to another, and to devise strategies to modulate them.

PMID:
16773072
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk