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Nutr Rev. 2006 May;64(5 Pt 2):S34-43; discussion S72-91.

Long-lasting neural and behavioral effects of iron deficiency in infancy.

Author information

  • 1Center for Human Growth and Development and the Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor 48109, USA. blozoff@umich.edu

Abstract

Infants are at high risk for iron deficiency and iron-deficiency anemia. This review summarizes evidence of long-term effects of iron deficiency in infancy. Follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences. Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function.

PMID:
16770951
[PubMed - indexed for MEDLINE]
PMCID:
PMC1540447
Free PMC Article
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