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Neurology. 2006 Jun 13;66(11):1766-9.

Endothelial dysfunction in MELAS improved by l-arginine supplementation.

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  • 1Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan.


The authors evaluated endothelial function in patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) by flow-mediated vasodilation (FMD) and found a significant decrease vs controls. Two years of supplementation with oral l-arginine, a nitric oxide precursor, significantly improved endothelial function to control levels and was harmonized with the normalized plasma levels of l-arginine in patients. l-Arginine therapy improved endothelial dysfunction and showed promise in treating strokelike episodes in MELAS.

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