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Brief Funct Genomic Proteomic. 2006 Mar;5(1):62-5. Epub 2006 Feb 22.

Multi-protein complexes at the beta-globin locus.

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  • 1Department of Genetics, The Anlyan Center, Yale University School of Medicine, 300 Cedar St., New Haven, CT 06510, USA.


Biochemical analysis of the beta-globin gene function has led to the identification of several multi-protein complexes at the locus control region (LCR), insulator and promoters. This review briefly summarizes these multi-protein complexes and discusses their contribution towards the regulation of the beta-globin gene expression.

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