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Am J Obstet Gynecol. 2006 Nov;195(5):1404-6. Epub 2006 Jun 12.

Prostaglandin F2alpha increases the sensitivity of the contractile proteins to Ca2+ in human myometrium.

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  • 1Department of Biological Sciences, University of Warwick, Coventry, UK.


It is not known whether agonists (other than oxytocin) increase the contractile protein sensitivity to intracellular calcium ([Ca2+]i) in human myometrium. We determined the calcium-tension relationship in the presence and absence of prostaglandin F2alpha (PGF2alpha). PGF2alpha increased the calcium sensitivity during both the contractile (rising) and relaxation (falling) phases of a contraction.

[PubMed - indexed for MEDLINE]
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