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Curr Opin Immunol. 2006 Aug;18(4):476-82. Epub 2006 Jun 12.

Imaging the choreography of lymphocyte trafficking and the immune response.

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  • 1Department of Physiology & Biophysics and Neurobiology & Behavior, University of California, Irvine, 92697, USA.


The functioning of the immune system depends upon exquisitely choreographed interactions between its cellular constituents. Two-photon microscopy now enables us to visualize cell motility and cell-cell interactions deep within intact tissues and organs, both in explanted preparations and in vivo. Real-time immunoimaging techniques have illuminated the roles of random and chemokine-driven motility for cellular search strategies, the complex dynamics of cellular interactions, and the micro-anatomical localization and control of lymphocyte trafficking. Recently, advances have been made in these areas of research, as exemplified by studies investigating T cell-dendritic cell interactions, T cell-B cell interactions, and the regulation of lymphocyte egress from the lymph node.

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