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Trans R Soc Trop Med Hyg. 2006 Dec;100(12):1159-63. Epub 2006 Jun 12.

Pharyngeal carriage of Neisseria meningitidis in 2-19-year-old individuals in Uganda.

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  • 1Division of Infectious Disease Control, Norwegian Institute of Public Health, Nydalen, Oslo, Norway. dominique.caugant@fhi.no

Abstract

In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2-19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.

PMID:
16765397
[PubMed - indexed for MEDLINE]
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