Abstract
K-48 is a new oxime-type compound to be used as an enzyme reactivator in the treatment of exposure to organophosphorous compounds. Plasma concentration of K-48 can be determined using reversed-phase HPLC. Analysis using octyl silica stationary phase and ultraviolet-absorbance detection is fast and simple. K-48 displays a relatively high dose-normalized area under the curve as compared to pralidoxime, which might be beneficial for an antidote. After i.m. administration of 50 mumol K-48, the time course of the concentration can be approximated by a straight line between 15 and 120 min meaning the elimination follows zero-order kinetics.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antidotes
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Area Under Curve
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Cholinesterase Inhibitors
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Cholinesterase Reactivators / administration & dosage
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Cholinesterase Reactivators / blood*
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Cholinesterase Reactivators / pharmacokinetics
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Cholinesterases / drug effects
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Chromatography, High Pressure Liquid / methods*
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Chromatography, High Pressure Liquid / standards
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Enzyme Activation / drug effects
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Female
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Organophosphorus Compounds / adverse effects
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Oximes / administration & dosage
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Oximes / blood*
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Oximes / pharmacokinetics
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Pharmacokinetics
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Rats
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Rats, Wistar
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Spectrometry, Mass, Electrospray Ionization
Substances
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Antidotes
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Cholinesterase Inhibitors
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Cholinesterase Reactivators
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K-48 compound
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Organophosphorus Compounds
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Oximes
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Cholinesterases