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Cell Death Differ. 2006 Aug;13(8):1403-8. Epub 2006 Jun 9.

The Bax pore in liposomes, Biophysics.

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  • 1Department of Physiology and Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

The protein BAX of the Bcl-2-family is felt to be one of the two Bcl-2-family proteins that directly participate in the mitochondrial cytochrome c-translocating pore. We have studied the kinetics, stoichiometry and size of the pore formed by BAX in planar lipid bilayers and synthetic liposomes. Our data indicate that a cytochrome c-competent pore can be formed by in-membrane association of BAX monomers.

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