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Cell Cycle. 2006 Jun;5(12):1281-5. Epub 2006 Jun 15.

Controlling stem cell proliferation: CKIs at work.

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  • 1Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.


The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.

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