Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. Epub 2006 Jun 12.

N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.

Temperini C, Innocenti A, Scozzafava A, Supuran CT.

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Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Sesto Fiorentino (Firenze), Italy.

Abstract

N-Hydroxyurea binds both to carbonic anhydrase (CA) and to matrix metalloproteinases (MMPs). X-ray crystallography showed N-hydroxyurea to bind in a bidentate mode by means of the oxygen and nitrogen atoms of the NHOH moiety to the Zn(II) ion of CA, participating in a network of hydrogen bonds with a water molecule and Thr199. A derivatized N-hydroxyurea showed low-micromolar affinity for several CAs. This simple zinc binding function may be exploited for obtaining potent metalloenzyme inhibitors, due to its versatility of binding to the metal ion present in the active site of such enzymes.

PMID:: 16759856; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

Bidentate Zinc chelators for alpha-carbonic anhydrases that produce a trigonal bipyramidal coordination geometry. [ChemMedChem. 2010]
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Review Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding.
Krishnamurthy VM, Kaufman GK, Urbach AR, Gitlin I, Gudiksen KL, Weibel DB, Whitesides GM. Chem Rev. 2008 Mar; 108(3):946-1051.

Structures reported by this article

N-Hydroxyurea, A Versatile Zinc Binding Function In The Design Of Metalloenzyme Inhibitors

PDB: 2GEH

Source: Homo sapiens

Method: X-Ray Diffraction

Resolution: 2 Å

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