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    Clin Infect Dis. 2006 Jul 1;43(1):99-102. Epub 2006 May 26.

    Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study.

    Rauch A, Nolan D, Martin A, McKinnon E, Almeida C, Mallal S.

    Source

    Centre for Clinical Immunology and Biomedical Statistics, Perth, Australia. S.Mallal@murdoch.edu.au.

    Abstract

    Abacavir therapy is associated with significant drug hypersensitivity in approximately 8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allele. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipients.

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    PMID:
    16758424
    [PubMed - indexed for MEDLINE]
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