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Biol Pharm Bull. 2006 Jun;29(6):1271-4.

Phytoestrogens from Aspalathus linearis.

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  • 1School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.


From the leaves of Aspalathus linearis, 24 known compounds and a new one, aspalalinin (25), were isolated. The structures of the compounds were determined mainly based on spectral evidence. The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity.

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