Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Cell Biol. 2006 Jun 5;173(5):767-80.

Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.

Author information

  • 1VTT Technical Research Centre of Finland, Medical Biotechnology, Turku FIN-20520, Finland.

Abstract

Dynamic turnover of integrin cell adhesion molecules to and from the cell surface is central to cell migration. We report for the first time an association between integrins and Rab proteins, which are small GTPases involved in the traffic of endocytotic vesicles. Rab21 (and Rab5) associate with the cytoplasmic domains of alpha-integrin chains, and their expression influences the endo/exocytic traffic of integrins. This function of Rab21 is dependent on its GTP/GDP cycle and proper membrane targeting. Knock down of Rab21 impairs integrin-mediated cell adhesion and motility, whereas its overexpression stimulates cell migration and cancer cell adhesion to collagen and human bone. Finally, overexpression of Rab21 fails to induce cell adhesion via an integrin point mutant deficient in Rab21 association. These data provide mechanistic insight into how integrins are targeted to intracellular compartments and how their traffic regulates cell adhesion.

PMID:
16754960
[PubMed - indexed for MEDLINE]
PMCID:
PMC2063892
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk